Depression What to Do When Nothing Works

Depression can be extremely serious and affects many people at different times in their life. Although we may shy away from the ‘label’ as many as 1 in 10 in the UK population will suffer from mixed anxiety and depression in any given year. So let’s take a look at depression what to do when nothing works.



You just feel miserable, can’t get up in the morning, don’t want to move, everything just shuts down, you lose your joy, you feel desperate, you cannot raise your energy.  There is huge introspection, sadness or loss, feelings of inadequacy, anxiety, insomnia, and no amount of “come on, cheer up” will make any difference.

depression what to do when nothing works


There are many causes, but one in particular which I will draw your attention to is often not well understood.  Most of the time depression can come about from some sort of loss.  Somebody dies, you lose a friend, you lose your job, your way of living, your house.  You lose your direction, your purpose.  Those are some of the emotional triggers; there are also several important physical triggers. 

Adrenal Fatigue

The adrenal fatigue so common in our hectic modern lifestyle can bring on depression.  You have been stressed and busy for so long you have depleted the resources for your adrenals to call upon.  As a result, the body will start to shut down and force you to do less thereby preventing further depletion of its precious resources.   Rebuilding your adrenals can take time due to the chronic exhaustion from the constant demands you have placed on the body. Life style changes, sometimes significant, are usually required here including good supplemental support.

Heavy Metal Toxicity

Heavy Metal Toxicity can build from the accumulation in the body of heavy metals such as mercury, cadmium, aluminium and lead.  Then there is the general chemical fog of pesticides, herbicides and solvents in the air we breathe plus the cleaners and fragrances used in our household products. These all have an impact by settling into the body and in the brain, especially in the pineal and pituitary glands, and the thalamus and hypothalamus which play an important role as an intermediary between the nervous system and the endocrine system (your hormones).

MSGdepression what to do when nothing works

A regular intake of MSG, found in many processed foods, has also been shown to trigger bouts of depression.  So once again a solid reason to eat a healthy varied diet and avoid processed foods and take-always.

White processed sugar is something that we need to look at when dealing with depression what to do when nothing works.

Most people would be surprised just how much white processed sugar can exacerbate depression.  The sugar gives you a glorious high but then the down that follows can grip you like a vice and may take 36 hours or more for you to pull yourself out of. If you cut out refined sugars from all foods, cakes, biscuits, cereals, sweets, tea and coffee, fizzy drinks …the whole lot, you will notice a significant difference in just a short time.

The more, live earth-grown, pasture-raised fresh food you can eat the better.  When you are in the depths of depression it is often difficult to even think about preparing meals, as you may not even feel hungry.  So get as much help and support as you can from family and friends. Diet really does have a huge impact – here are some foods which can really support people with depression:

  • Wild Blueberries
  • Spinach
  • Hemp Seeds
  • Coriander/Cilantro
  • Walnuts
  • Coconut Oil
  • Sprouts
  • Kale
  • Apricots
  • Avocados


Supplements for depression what to do when nothing works:

Supplementation may often be helpful and this should be done with the support of your health practitioner.  Below are listed some of the supplements commonly found useful:


  • GABA (Gamma Aminobutyric Acid) supports the neurotransmitters, calms down the central nervous system and helps regulate sleep patterns and quality.



  • EPA and DHA for repairing and strengthening the central nervous system. Plant based sources are best.


  • B Complex helps to protect all areas of the body and especially supports the brain and brain stem.


  • Magnesium calms down the central nervous system and helps to relax muscle tension.


  • Rhodiola can help to strengthen the endocrine system such as the thyroid and adrenal glands and assists with the vascular system.


  • Lemon Balm is great for reducing inflammation and supporting the central nervous system


  • Vitamin C best taken in Ester C formulation (as it is kinder on the stomach). Supports damaged neurotransmitters, adrenal glands, liver and assists with detoxification and inflammation.


  • Licorice root is great for supporting the endocrine system and the digestion.




Lastly, ensure you are drinking plenty of good quality water.


depression what to do when nothing works

Depression What To Do When Nothing Works

Depression what to do when nothing works

So, perhaps in your search for improved health and freedom from depression and what to do when nothing works, you have incorporated all these good lifestyle changes and tried some, or maybe most of the supplementation –  yet you still lack energy all the time, you still wake-up tired, depressed and nothing seems to touch you.  If you feel like you have got a flat battery all the time, then you may be someone who would benefit from Mitochondrial Therapy.

Mitochondria are the “Powerhouses of the Cells”, found inside the cells of every complex organism.  They are specialized parts of cells that use oxygen and turn “fuel” (carbohydrates, fats, proteins) into forms of chemical energy that the body can use for all it’s processes, essentially for living. Mitochondria produce about 90% of the energy that cells need to survive.  As well as providing cells with energy, mitochondria also have other extremely important roles. They produce chemicals that your body needs for other purposes, break down waste products so they are less harmful, and recycle some of those waste products to conserve resources.



Mitochondria also have a special role in making cells die (apoptosis). This may sound strange, but it is vital for the processes of growth and development. Sometimes cells don’t die when they should, and start to grow uncontrollably. This is how a tumour starts to grow, so we can see that mitochondria play an important part in cancer.

Once we understand that correctly functioning mitochondria are essential to optimal human health, we can see how when they go wrong serious disease can result.

One method of investigating how well your mitochondria are working is to utilise an HRV (heart rate variability) Test.  This simply involves you sitting in a chair with sensors on your wrists and ankles and a 5-minute recording of your heart rate variability is made with a Vericard machine. The collected data is then processed and interpreted to give a picture of how well the body’s fundamental regulatory processes are working. 

This will start to give a clearer picture as to why your hormone and immune systems may be having problems adapting to the stress you are placing upon them. It will show why you may not be able to lose weight and why you have no energy, which in turn will affect your ability to regenerate and repair. If you have a flat battery, the power that is available will only be used for supporting the most important systems in the body.  However, once the areas of depletion are discovered, then protocols based upon bespoke supplementation can be offered to address these areas enabling you to take back your energy and your joy.

Mitochondrial Therapy for depression is the most powerful technique I have seen in 20 years of practice and I am extremely pleased to be able to offer you this.  For more in depth information, give me a call and book an appointment.

That concludes my blog about depression what to do when nothing works, I am sure you would have found some useful information in here and as always I am here to talk.

Below is a video I have done to accompany the blog post,please have a look and do not forget to subscribe to my YouTube Channel.



[1] The Health & Social Care Information Centre, 2009, Adult psychiatric morbidity in England,   Results of a household survey





Depression What to Do When Nothing Works
Depression What to Do When Nothing Works

Depression can be extremely serious and affects many people at different times in their life. Although we may shy away from the ‘label’ as many as 1 in 10 in the UK population will suffer from mixed anxiety and depression in any given year. So let's take a look at depression what to do when nothing works.

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